Renting a car and driving in Chile is, generally speaking, easy and convenient. Santiago streets are well organized with street signs, but, like in any big city, driving during rush hours can be stressful. Drivers normally drive fast although traffic rules are respected, especially the STOP and YIELD signs, as well as pedestrian crossings. Urban buses, called "Micros" are a menace, try to avoid close contact with them, they are easily spotted, as they are painted yellow and white.

You should always carry your driver’s license and vehicle registration, since police check frequently. Most countries driver’s licenses are honored by car rentals and police controls, although strictly speaking an international license is required.

A seat belt is mandatory for the driver and companion. Smoking, using a cellular phone or a Walkman is prohibited for the driver. Chilean policemen (Carabineros de Chile) will schedule an appointment for you to speak with the local Judge in case of an infraction and the driver’s license is always taken. Carabineros are always polite and comprehensive especially with foreigners.

Driving under the effects of alcohol is a severe offense. You could be fined or arrested depending on the level of alcohol intoxication. Speeding is also punishable. The maximum speed, unless otherwise stated, is 120 km/h (75 mph) on highways and 70 km/h (45 mph) in urban areas.

There are many agencies that rent cars on an hourly, daily, weekly, or monthly basis. They generally require the driver to be over 21 years of age, have a valid national or foreign driving license, and a major credit card as a guarantee.